Dec 02, 2008 · The force generated by a muscle depends on the total number of cross-bridges attached. Because it takes a finite amount of time for cross-bridges to attach, as filaments slide past one another faster and faster (i.e., as the muscle shortens with increasing velocity), force decreases due to the lower number of cross-bridges attached. the cytoskeleton) can be separated from the muscle stiffness stemming from active binding of myosin cross-bridges to actin ﬁlaments and that from the ECM (15). The complex and compartmentalized pathways may present challenges to our understanding of regulation of smooth muscle contraction; however, they also provide opportunities for ...
When a muscle is in a resting state, actin and myosin are separated. To keep actin from binding to the active site on myosin, t ropomyosin blocks myosin binding sites on actin molecules, preventing cross-bridge formation and preventing contraction in a muscle without nervous input. Troponin binds to and regulates tropomyosin. Eccentric contractions are stronger than isometric and concentric contractions partly because, in eccentric contractions: a) More muscle fibres within a muscle are activated. b) Within each muscle fibre, more cross-bridges are attached to actin at a given time.
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